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Ibrutinib-biotin 依鲁替尼-生物素

货号:HY-100342品牌:皓元(MCE)

商品货号:

规格:

售价:

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HY-100342

5mg

6375.00

HY-100342

10 mM * 1 mL

11286.00

HY-100342

10mg

9350.00

HY-100342

50mg

34000.00

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Description

Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.

IC50 & Target

IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)[1]

In Vitro

Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells[1].

Molecular Weight

1097.37

Formula

C₅₆H₈₀N₁₂O₉S

CAS No.

1599432-18-4

SMILES

O=C(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)=O)NCCCCN(C)C/C=C/C(N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C7=C(N)N=CN=C74)C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month
Solvent & Solubility

In Vitro: 

DMSO : 50 mg/mL (45.56 mM; Need ultrasonic)

Preparing 
Stock Solutions

ConcentrationSolventMass1 mg5 mg10 mg
1 mM0.9113 mL4.5563 mL9.1127 mL
5 mM0.1823 mL0.9113 mL1.8225 mL
10 mM0.0911 mL0.4556 mL0.9113 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.


    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.28 mM); Clear solution


  • 2.


    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.28 mM); Clear solution


  • 3.


    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.28 mM); Clear solution